Quality Improvement Project on Patient Falls in a Medical-Telemetry Unit

This paper will summarize the quality improvement falls prevention project conducted by a group of University of San Francisco Clinical Nurse Leader (CNL) students. Falls in the acute care setting are a major issue in the current health care system and are a main topic of interest for CNL students to address in order to demonstrate their competency in risk reduction, health promotion, and evidence-based practice. A large, metropolitan hospital uses the Morse Fall Scale to assess patients for fall risk factors. On a medical-telemetry floor, fall incidence rates are increasing from the previous fiscal year. Due to the negative impact of falls on patient outcomes, the CNL students conducted a systematic analysis of the problem. The results were used to design, implement, and evaluate an evidence-based practice intervention to address the root cause of falls on the unit. The systems theories used in this quality improvement project are Chaos Theory and Kotter’s Eight Step Change Model

Red quasars blow out molecular gas from galaxies during the peak of cosmic star formation

Recent studies have suggested that red quasars are a phase in quasar evolution when feedback from black hole accretion evacuates obscuring gas from the nucleus of the host galaxy. Here, we report a direct link between dust-reddening and molecular outflows in quasars at $z\sim2.5$. By examining the dynamics of warm molecular gas in the inner region of galaxies, we detect outflows with velocities 500--1000 km s$^{-1}$ and infer timescales of $\approx0.1$ Myr that are due to ongoing quasar energy output. We observe outflows only in systems where quasar radiation pressure on dust in the vicinity of the black hole is sufficiently large to expel their obscuring gas column densities. This result is in agreement with theoretical models that predict radiative feedback regulates gas in the nuclear regions of galaxies and is a major driving mechanism of galactic-scale outflows of cold gas. Our findings suggest that radiative quasar feedback ejects star-forming gas from within nascent stellar bulges at velocities comparable to those seen on larger scales, and that molecules survive in outflows even from the most luminous quasars.Comment: Submitted to MNRAS. 18 figures and 3 table

Red quasars blow out molecular gas from galaxies during the peak of cosmic star formation

Galaxie

American Association of Colleges of Pharmacy (AACP) Co-Curriculum Toolkit

The co-curriculum is intended to run parallel to the formal curriculum and support the development of students’ professional knowledge, skills, abilities, behaviors, and attitudes, including scientific foundation, knowledge application, and practice competencies. Additionally, the co-curriculum can also support proficiency in skills and achievement of competencies that are concurrently taught within the formal curriculum. ACPE evaluates the way programs assess students’ acquisition of knowledge and application of knowledge to practice within co-curricular experiences and especially how they advance the professional development of students within affective domain areas of learning

Search for CP Violation in the Decay Z -> b (b bar) g

About three million hadronic decays of the Z collected by ALEPH in the years 1991-1994 are used to search for anomalous CP violation beyond the Standard Model in the decay Z -> b \bar{b} g. The study is performed by analyzing angular correlations between the two quarks and the gluon in three-jet events and by measuring the differential two-jet rate. No signal of CP violation is found. For the combinations of anomalous CP violating couplings, ${\hat{h}}_b = {\hat{h}}_{Ab}g_{Vb}-{\hat{h}}_{Vb}g_{Ab}$ and $h^{\ast}_b = \sqrt{\hat{h}_{Vb}^{2}+\hat{h}_{Ab}^{2}}$, limits of \hat{h}_b < 0.59$and$h^{\ast}_{b} < 3.02$ are given at 95\% CL.Comment: 8 pages, 1 postscript figure, uses here.sty, epsfig.st

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin